Kensington slim type keyboard

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Feline antibiotics

Symptoms and cat-like facial treatments of problems of Symptoms and cat-like facial treatments of problems of Précédemment skin, of the differentials of the cat-like facial prurit were discussed to include ectoparasites such as the allergy of chip, the otodectes, Notoedres and the cheyletiella, the allergy of food, the atopie including/understanding the possible allergy less common differentials include infections such as the dermatophytose, viral, and the bacterial pyoderma, the dermatite of Malassezia, the foliaceus of Pemphigus (PF) and the facial dermatite diseases resemble including/understanding the foliaceus of Pemphigus and the bacterial pyoderma it can be difficult to differentiate that. The dermatophytose in the cats can have much various presentations to extend from the covering lesions of a crust major to the dermatite miliary with asymptomatic. It is thought that that would be more common in younger cats. Us all should probably carry out cultures more wood is to gain a false direction of safety bus of the more fungic species do not enter in fluorescence than normal "balance the" can ignite under the light of out of wood, however a fluorescence green apple is what is considered positive in the dermatophytose with canis of microsporum. Before employing the light of out of wood, it is important to allow in the light of heating during five to 10 minutes or a false negative result can occur can also occur if shampoos or the topicals. to diagnose the dermatophytose include a trichogram (examination of the oil hairs under the microscope seeking the fungic elements in the axis of hair), the fungic culture by using the technique of Mackenzie to use a brush with teeth to comb the cat for one period of five-minute then establishing the hairs/bristles in the fungic culture medium, and the biopsies of skin with. Fungic cultures should be maintained in a place dark and wet and to be examined during one ten days period subjected to the laboratory for the identification to be sure that the dermatophytose is present and not the contaminants which can dermatophytose were discussed lengthily in the past. Only the therapy topics with the focal sectors médicalement affected can give a false direction of safety while other fields of the infection can brew, however these sectors are not. I prefer systemic antifungals such as Itraconazole 5-10mg/kg/day with the weekly lime sulphur plunges. The insulation of the affected cat is imperative enzymes of liver must be supervised with the use of Itraconazole just as achieves accounts of blood with griséofulvine for the pancytopenia idiopathic in particular at. to be effective for the dermatophytose, however a personal experiment suggests dubious results two negative fungic cultures after the treatment to ensure the problem of the dermatophyte of the patient solved is important. The bacterial pyoderma in the cat certainly is not as generally diagnosed as in the dog, but is always a differential to be considered in the cat-like facial prurit. The simulans of staphilococcus is resident normal of identified in the cats with patient lesions of pyoderma. are usually older cats and the lesions can be composed of the épidermiques collarettes or deep pyoderma with draining areas brought back, response to the antibiotic therapy was important in. The other diagnosis included the biopsies of skin which brought back a folliculite, a perifolliculitis or a dermatophytose must be eliminated before the diagnosis of a pyoderma bacterial primary education can be made. The viruses are the important pathogenic microbes in respiratory infections in the cats, however seldom cause. The viruses which can affect the skin in the cats include the poxvirus, the herpes and the calicivirus. These organizations can cause lesions of skin as well as lesions of mucous membrane. of skin and the test of PCR can be useful by carrying it out. The therapy is composed of antibiotics, Des. nonhealing of skin, the statute of FeLV and of FIV of the patient would have. The infections of infectionsMalassezia of Malassezia in the cats affecting the facial folds in particular can play a part of accompaniment in the idiopathic facial dermatite of the cat. The affected cats marked the dark material deposited in the facial folds sometimes accompanied by the erythema, of. Malassezia is sometimes insulated and the treatment with drugs of antiyeast can help in some patients to have the secondary bacterial participation, however the antibiotics can only produce the partial resolution. The biopsies of skin bring back the acanthosis, the degeneration hydropic with the basic cells dyskeratotic, hyperplasia sebaceous, with a mixed diffuse ignition therapies included the systemic steroids, the oral antifungals, the modes hypoallergenic and the oral cyclosporine. Unfortunately the etiology is unknown and the disease can. Included in problems of Malassezia in the cats is a yeast otitis/dermatitis in particular. It is possible that when the cat toilet, it transfers yeast starting from the ears to the sector of the otic preparations from Anti-yeast with the ketoconazole or the oral itraconazole can be useful. Although the majority of the veterinary surgeons regard as being the foliaceus of pemphigus (PF) rare, it is really not rare to see this disease in the cats with a facial dermatite. One reported that up to 80 percent with the lesions to cover pinna of ear, face, surrounding the nipples and them. Cats of any age can be. The patient can be feverish and to have a leukocytosis, a éosinophilie and/or a soft anaemia cytology of the lesions, the cells acantholytic with neutrophiles or the eosinophils can be present a practice as regards reference, the history includes that the patient was at the beginning sensitive to the injections steroids, and they are usually referred because of the tolerance. The biopsies of skin are necessary to make the diagnosis, and it is useful to have the patient as a long time in addition to steroid like possible to obtain a diagnosis. Biopsies of skin of the crusts or if the present, a pustule intact, is subjected in 10 percent of formalin with a complete history histopathologic include the pustules subcorneal made up of périvasculaire to the neutrophiles to be composed of ignition and with also being carried out to eliminate the dermatophytose since some fungic species produce the acantholysis. treatment from the PF includes the oral steroids such as the dexamethasone at the beginning to enter the disease the handing-over. The reduction or the withdrawl of the steroids is the final goal since they can encourage the diabetes in the cat so long term necessary in some patients who cannot be separated. Chlorambucil, of the complete accounts of blood must by practice be examined to ensure the reduction of red globules, of cells of doxycycline 5 mg/kg offered which can have a certain activity in the action to avoid autoimmune disease and of light of. The sun, at least in the human autoimmune diseases, can cause a flareup disease. it is not known only which releases autoimmune reaction of the adherence between the epithelial cells which defines the PF, but factors such as drugs, vaccinations, insect bites or the fundamental neoplasia can play a part in. Still as with the majority of the problems of derm, two identical in patients of aspect can in fact (and usually) of having the various diseases facial cat pruritic, the ectoparasites are probably the first differential to be eliminated and a hunting for chips, Cheyletiella, demodex or Notoedres should be undertaken need to remember to the responsibility with underdiagnosing dermatophyte-in the fact my receptionist have right adoptee a kitten without any lesion of skin two weeks ago, maintaining the family whole has lesions of "tinea tonsurante" and the cat has two to three hairs fluorescing on the muzzle. not to say we let us have need for culture fungic all the kittens which we examine, but explain at least the possibilities of any dermatophytose involute of kitten after differentials of the cat-like facial prurit can be eliminated near in tests from office such as scrapings from skin, combings, trichograms, fungic cultures, the test of skin or the ELISA. the tests intern are negative or not very conclusive, the biopsies of skin are usually useful by carrying out the diagnosis mycetoma in symptoms and treatments of Vie cats With a Cat Diabetic Books On reserved Cats And Kittens - Health Of Veterinary Cat | Of Cat this site in your preferred language. 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Action verbs

. - If you are trying Verbo in the variable sense that denotes action ("to carry", "to read"), occurrence ("decomporsi", "to spark"), or one be of the being ("to exist", "living", "to be"). Of continuation the norms are listed of. The various modalities with which an action can happen come yields with the various oral ways. They are the seven ways of the Italian language. Ended ways are called therefore because their desinenze define always one person (, before second or a third) and number (singular or plurale). It is the way of the truth, of the emergency, the certainty), calls to you therefore because they do not have need of a verbo. It is the way of the possibility, desires, the opinions. It is the way of the actions that happen to one given condition. It is the way of the demands, the orders, of invites. It has only the second person (you and you) and a single time. Some grammars contemplate a future imperative of all the identical one to the simple future of the indicative. These ways do not allow to identify the person and the number (made exception for the participio, in which the singular one from the plurale can be distinguished).), but it can be used also like main verbo in order to indicate orders, desires, etc (p. Of it exist the time present ("to reflect") and last ("to have riflettuto"). and, for this, it can indicate the number sometimes and also the kind (p., the participio eaten indicates feminine a singular one). It is used with the auxiliary verbos in the construction of the composed times. It has two times, the present ("reflecting") and the past ("riflettuto"). It is used in the subordinate clauses in order to express a sure type of relationship with resisting. It has two times: the present ("reflecting") and the past ("having riflettuto"). second (- ere), the composed one for the greater part from irregular. the verbos to be and possession have one own coniugazione. Three ways exist to conjugate the verbos: in order to express an action completed from, the verbos in the active shape are conjugated. The reflecting shape in its turn can be:. appearing: the particles me, you, us, do not carry out you the function of complement object, but of ("Piero dry up the hats" = "Piero dry hats to himself", where "the hats" are the complement object and "" = "to himself" it is the term complement). mutual: the action is completed and endured scambievolmente from two subjects ("Piero and Carl greets" = "Piero greets Carl and Carl greets Piero"). Attention: some verbos have a pronominale shape that is similar to that reflecting one but it enters not there at all: the particles me, you, us, make part you of the same verbo. As an example, "pente Piero" does not mean "pente Piero if same": in fact "to repent" it is a verbo that has the pronominale shape. The verbos that faithfully follow the model of the own coniugazione are said regular. The tables of the coniugazioni of the regular verbos are found. The difettivi verbos are those verbos that totally lack some oral voices or entire times to use (use, use, used, are usual. to urge (urge, urge, urged, will urge. to concern (concern, concern, concerned, will concern. to vigere (vige, vigeva, vigerà, enforced. to compete (compete, competed, will compete, competent. to tangere (tange, tangeva, tangerà, tangent. soccombere (soccombe, soccombeva, soccomberà, soccombente. to dirimere (dirime, dirimeva, dirimerà, dirimente. the overabundant verbos are those that, maintaining the same one meant, have two various desinenze for the present infinite and therefore belong to two various coniugazioni. The classic example is that one of the verbo to starnutare/starnutire. Attention, but: some verbos are apparently overabundant, because the two shapes have mean to you various. As an example, to redden wants to say "to render red", while to blush it means "to become red". The verbos are preached to you that have independent meaning, forming what in. Those verbos are copulati to you that do not have independent meaning and that they acquire it alone in presence of an adjective and/or a sostantivo. The copulativo verbo for excellence is being, than, when it comes joined to the name or the adjective (nominal part), comes defined copula. "He was a navigator" comes defined preached nominal, "he was" is the copula and "a navigator" is the nominal part. Also other verbos can be copulati to you (to seem, to appear, to grow, to turn out, to become, etc.) when they have need of a name or an adjective in order to complete theirs meant. If you said "Pierino has become", that would not have sense. "the great" word completes the meant one, for which it says that it is Is from noticing that second some grammarians us solo to be is from considering itself like a copulativo. They are verbos copulati to you also: to seem, to seem, to become, to become, to be born, living, to die, to go, etc. They can moreover resist a predicativo complement of the subject, but only if it conjugates to you in the passive shape, the verbos: _ named to you: to nickname, to call, to say, ecc.(es:la city of New York is nicknamed the "Great Apple") _ elective: eleggere, to create, to name, ecc.(es: My uncle has been elect mayor) _ estimated to you: to judge, to believe, to name, etc (es: The culprit was judged innocent) _ effetivi: to make, to render, etc (es: That author has been rendered celebre from its first novel) is a particular case, in which the verbo to be takes the meant one to exist. A verbo is transitivo when the action "directly journeys" on something or someone. in other words, when the verbo can resist one. The verbo "to direct", as an example, is transitivo because a complement resists object like "a company", "an orchestra", "the traffic", etc. The verbo "to swim", instead, is intransitivo because a complement cannot resist in some way object. Some transitivi verbos, in sure cases, can have intransitivo meaning. We can say: "Piero reads the daily paper", but we can only say: "Piero reads", in order to say that it is engaged in the activity of the reading. Analogous it can be said: "Baglioni sings This small great love", but if we remove the complement object, Baglioni remains "sings", that it means that the activity of Baglioni is to sing. ("Living" and "life" have the same root. (Between "crying" and "tears" there is a meant nexus of. the verbos that indicate atmospheric conditions or other natural events: piove, tuona, it hails, it snows, it dawns, ago warm, etc. the verbos constructed from the particle and the third singular person of the verbo in issue: "it is eaten well from these you leave", "Usually is not studied gladly". Other verbos are improperly impersonal because their subject is an entire one. the verbos that indicate necessity, accadimento, appearance: "sùbito Must leave", "Happened that franò the mountain", "Seemed that all it was perfect". the formed locuzioni to be, to go or to be, followed from an adjective (are right, are necessary, are beautiful), from a sostantivo (are hour, are time) or from an adverb (go well, are badly). The verbos to be and to have use in the formation of the voices of the times composed of all the other verbos: in these cases they are said (because they are of aid for the other verbos). In case of doubts, it is however better to consult the dictionary. Literally they "serve" to other verbos in order to enter in the specific one. The verbos you serve them of the Italian language are: it must, to be able, to want, to use, to know, to prefer, to wish, to dare. The fraseologici verbos (or aspettuali) are those that, places before a verbo to the infinite, of it specify a temporal aspect. Some example: to be about itself to, to be for, to begin to, to put themselves to, to persist in, to continue to, to stop of, to end of, etc. A particular fraseologico is that format the verbo to be followed from the gerundio ("is going to Ventimiglia"). The verbos caused to you indicate that the action is caused from the subject, but that it does not complete it he directly. I swear to have said the truth, I promise to come to more soon, Deny every thing are all examples of performativa function of the verbo. Other verbos that to the first person of the indicative present assume performativa function are as an example: to say, to admit, to assert, etc. Last modification for the page: 16:41, 22 feb 2008. All the witnesses are available in the respect of the terms of.

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RALEIGH ORTHOPEDIST

Regionally variability into use OF A novel OF thoracolumbar spine fractures assessment: United States versus internationally surgeons. "style="vertical align:middle. margin-right:3pt ". ©. 2007 Ratliff et aluminium licensee BioMed cent ral Ltd. regional variability into use OF A novel OF thoracolumbar spine fractures assessment: United States versus internationally surgeons and trauma Study Group Spine department OF Orthopaedics, Thomas Jefferson University hospital, Philadelphia, the USA department OF Orthpaedics, Cedars Sinai Medical center, Los Angeles, the USA department OF Orthpaedics University OF North Carolina, Raleigh, the USA department OF Orthpaedics University OF Pittsburgh, Pittsburgh, the USA department OF Neurosurgery, Kansas University, Kansas town center, the USA department OF Orthopaedic Surgery, University OF Toronto, Toronto, Ontario, Canada. OF Othopaedic Surgery, Brigham and Women's hospital, Boston, the USA. This is at open ACCESS article distributed more under the of term OF the Creative Commons Attribution License (.), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly CIT OD "style="vertical align:middle. margin-right:3pt "Considerable variability exists into clinical approaches ton of thoracolumbar fractures. Controversy in evaluation and nomenclature contribute ton this confusion, with significant differences found between physicians, between different specialties, and in different geographic region. A new classification system for thoracolumbar injuries, the Thoracolumbar Injury Severity Score (TLISS), which recently described by Vaccaro. NO assessment OF of regionally differences has been described. Incoming goods report regionally variability into use OF the TLISS system between United States and non US surgeons. spine surgeons (8 neurosurgeons and 20 orthopedic surgeons) reviewed 56 clinical thoracolumbar injury case histories, which included pertinent imaging studies Twenty eight. Cases were classified and scored using the TLISS system. The reliability and treatment validity OF the TLISS which assessed. Surgeons were grouped into US (n = 15) and non US (n = 13) cohorts. inter+ more rater agreement on management which moderate, although it tended tons more higher in US surgeons. inter+ more rater agreement between US and non US surgeons which similar tons within group inter+ more rater for all categories agreement. Intra more rater reliability for management which substantial in both US and non US surgeons. The TLISS of incorporates generally accepted feature OF spinal injury assessment into A simple patient evaluation tool. The TLISS May improve communication between health providers and May contribute ton more efficient management OF thoracolumbar injuries. "style="vertical align:middle. margin-right:3pt "Controversy persists with rain pool of broadcasting corporations ton treatment OF of thoracolumbar injuries. The diagnosis and definition OF clinically significant spinal instability remains unclear and of poses A SOURCE OF frequently disagreement into the literature. Some patients, more however, ultimately fail conservative treatment, developing symptomatic late deformity or instability. Modern operational techniques allow for restoration OF normally spinal alignment, correction OF instability, and decompression OF again ral of element. Determining prospectively which patients acres prone tons developing instability and hence might benefit from surgical treatment remains contentious [. Adding ton confusion over patient selection, NO consensus exists as ton choice OF treatment into thoracolumbar injuries. The therapeutic approach tons of thesis patients is hampered by lacquer OF accepted nomenclature and OF A useful and clinically valid classification system for thesis of injuries. While numerous classification system have been devised, each poses problem in implementation [. Many of system of acres overly complex, limiting their utility. Others omit important portion OF standard clinical decision making. Most classification pattern fail tons suggest treatment option [. A recently described treatment algorithm May aid in treatment OF thesis patients. Relevantly literature on thoracolumbar trauma, classification, and treatment which reviewed. A classification scheme and treatment algorithm were described (figure it patient is at 18 y/o paints who presents after A engine vehicle accident. Representative sagittal (A), coronal (B) and axially (C) computed tomography image were obtained. A compression fracture with angular deformity RK T5. Second illustrative case OF TLISS use. Patient is A 21 y/o paints who presents after A engine vehicle accident. The patient which neurologically intact. Representative sagittal (A) and axially (B) computed tomography and sagittal T2-weighted magnetic resonance. Initially testing showed poor reliability for the injury mechanism sub score OF the measure. A separate system, the Thoracolumbar Injury Severity and Classification Score (TLICS), has been recently forwarded [. Good validity in different specialties and different training level have been described, with similarly adequate reliability [. validation across geographic boundaries has emergency been assessed. Considerable geographic variation is consistently reported in surgical treatment OF spinal disorders. Incoming goods compare the inter and intra more rater reliability OF the TLISS within and between US and non US surgeons. Incoming goods demonstrate moderate ton substantial reliability into the use OF the scale and high treatment validity, as assessed by surgeon agreement with the algorithm's management recommendation. The TLISS is A promising tool into the evaluation OF spine trauma patients. "style="vertical align:middle. margin-right:3pt ". In order ton validate the management recommendations OF the TLISS algorithm, A booklet OF 56 thoracolumbar trauma TIC injury case studies which prepared. The case vignettes detailed the patient's age, description OF the trauma TIC injury, and neurological exam. Imaging of studies, including plain radio graph, CT, and MR (sagittal T. The cases were distributed ton surgeons for classification and grading using the TLISS algorithm. The finally severity score which used ton determine the recommendation for nonoperative or operational treatment according ton the treatment algorithm described in Table. Twenty eight surgeons completed the vignettes. The results were analyzed ton determine inter+ more rater reliability, and by cent agreement with the finally treatment recommendations. Three months more later, the numerical order OF the cases which scrambled and of lampoon were redistributed. Twenty two OF the original 48 surgeons who participated into the development OF the classification system completed both surveys. Their results were analyzed ton determine intra more rater reliability. Ton assess possible regionally differences into the validity and reliability OF this system, physicians were grouped into US and non US cohorts. The US cohort included surgeons from A variety OF trauma of center. The internationally group included surgeons from Canada, Australia, Germany, Mexico, France, Sweden, India, and the Netherlands. The DATA were then analyzed using SPSS software ton determine by cent agreement, unweighted Cohen's kappa, kappa with linear weighting, and Spearman's climb order correlation.0 (complete disagreement) through 0 (chance agreement) tons of 1. A guideline for interpreting Cohen's kappa VALUES is summarized in Table. For significance tests, all unweighted coefficients were converted into Fisher's of z-scores, and the difference into z-scores which divided by standard error "style="vertical align:middle. margin-right:3pt "inter and intra more rater agreement between the cohorts is reviewed in Tables. General results OF kappa scoring between the groups has been previously reviewed [. Non US spine surgeons had greater inter+ more rater reliability on mechanism sub score (p <. 0.05 as assessed by %), while US agreement surgeons had greater inter+ more rater reliability on neuro status (p <. 0.05 as assessed by % and Spearman's r) and PLC agreement integrity (p <. 0. US versus non US inter+ more rater agreement US versus non US intra more rater agreement absolute ones inter+ more rater agreement among non US surgeons on the finally TLISS score which more greater (p <. 0.05), totally TLISS of scores but more better correlated among US surgeons (p <. 0. With rain pool of broadcasting corporations ton the algorithm's finally recommendation for treatment (operational vs. non operational), inter+ more rater agreement within the US physician group and non US group which 75. inter+ more rater agreement on management between the groups which 74. Between the two groups, greatest agreement which found in assessment OF neurological status (96th thesis differences reached statistical significance as assessed by % for mechanism and agreement neurological status. Differences into intra more rater correlation reached statistical significance on neurological status, PLC, and totally TLISS (Table. Intra more rater reliability on management into the two cohorts which similar, with 78,8% intra more rater agreement in US surgeons (Cohen's kappa. US surgeons agreed with the management recommendation OF the TLISS in 93.4% OF the cases and non US surgeons agreed with the algorithm larva were in 91st "style="vertical align:middle. margin-right:3pt "initial attempts RK thoracolumbar fracture classification by Bohler in 1930, who classified fractures into five injury type based on anatomic appearance and mechanism [. forwarded the AO classification, using A mechanical anise TIC approach ton divide fractures into A totally OF 53 potential patterns based upon 3 injury categories and of 3 animal OF subcatagorization [. A separate load sharing classification OF spinal injury has thus been described [. The most commonly used system of acres Denis ' three column model OF spinal stability and the AO classification. The AO system has poor inter and intra more observer agreement [. Use OF 53 different fracture patterns is unwieldy and appears counterintuitive. This of makes routine clinical use OF the scale impractical. The Denis system May oversimplify complex fractures, and May emergency accurately assess need for operational intervention [. The TLISS clinical algorithm assesses thoracolumbar injuries based upon three accepted clinical decision making criteria: 1. Mechanism OF injury as determined by imaging studies, 2. Thesis criteria were thought tons independent predictors OF patient clinical outcome. Subgroups for scoring were developed within each component. POINTS of acres assigned into the treatment algorithm cumulatively for each criterion. Finally recommendation for is based upon finally injury score (1 and 2) treatment. The mechanism OF injury describes fracture pattern based upon three general descriptions, similar ton the AO thoracolumbar injury classification: 1. Angulation RK the fracture site for compression injuries indicates more greater instability, and separately May ADD 1 POINT ton finally TLICS score. Complex fractures May combine more than one OF the three basic morphologic element. In thesis cases, only the highest category is scored. Thoracolumbar injury severity score (TLISS) The PLC is composed OF the ligamentum flavum, the facet joint of capsules, and the interspinous and superspinous ligaments. The PLC is quantified in the TLICS as intact, indeterminate, or disrupted (Table. Imaging via MRI, CT, plain film, and physical exam (detecting A palpable gap between spinous processes) acres used ton evaluate the PLC. Presence or absence OF neurological deficit is independent on indicator OF the severity OF thoracolumbar injury. More severe injuries merit more higher scores, with incomplete spinal cord and cauda equina injuries scoring highest into the algorithm (Table. The injury score is obtained via summation OF individually element. A cumulative score OF 3 or less suggests A non operational injury, while A score OF 5 or more greater suggests surgical intervention May necessary (Table. Scores OF of 4 acres indeterminate, and May treated surgically or conservatively [. illustrative ones of cases of acres reviewed in Figures. Reliability and validity OF the TLISS The TLISS scale has been evaluated for both inter and intra more rater reliability. Acceptable reliability which found and surgeons agreed with the algorithm's treatment recommendation in more greater than 90% OF of cases [. Greater than 90% OF surgeons in each specialty were found ton agree with the TLISS management recommendations [ ], and the same trend OF outstanding construct validity is reported here when comparing US and non US surgeons. In contradistinction tons of OTHER classification schemes, the TLISS has demonstrated acceptable intra and inter+ more rater reliability and appears usable across specialty boundaries. This manuscript is the roofridge ton assess geographic differences using the TLISS thoracolumbar injuries in approach tons assessment tool. As noted by silk worm, "medicine is evidently A local phenomenon" [. Geographic of influences on choice OF surgical and medical therapies of acres significant. Geographic location consistently predicts yearly advice OF spine surgery [. advice OF surgery acres noted ton increase linearly with supply OF orthopedic and neurosurgical spine surgeons [. Similar geographic variation occurs in coronary artery bypass graft procedures, general orthopedic procedures, and medical treatment OF acute myocardial infarction [. parallel findings in system without financial incentive for clinical productivity would seem ton indicate on intrinsic regionally variability into health care use [. Geographic variation thus is found in development and adoption OF new technology [. Geographic of differences persist in evaluation and management OF trauma TIC of injuries. In A multi-center review OF trauma TIC spine injuries, NO consensus which found as tons optimally surgical timing [. Treatment approach, including imaging, seemed tons vary by research site [. For the TLISS ton A useful paradigm for assessment and management OF thoracolumbar injury, it must bridge thesis significant geographic differences in approach tons spinal pathology. The system must demonstrate adequate internationally reliability. To cathedral TIC versus internationally reliability and validity OF the TLISS incoming goods compared reliability and validity OF the TLISS in US and non US surgeons, eat-sing both inter and intra more rater reliability. inter+ more rater on management agreement within the US physician group and non US group which 75. Pair of overalls correlation on management between the groups which 74,2%, indicating adequate validity OF the measure. The TLISS of provides reliable and valid initially treatment recommendations, irrespective OF more rater geography. Thesis and similar results have lead tons of A recent modification OF the TLISS system [. Inferring the mechanism OF injury from initially imaging modalities May difficult. Into fact, this is the reliable sub score among both US and non US leases surgeons. Hence, injury morphology has been substituted for injury mechanism. Injury morphology is based simply upon the appearance OF the fracture or dislocation on imaging studies (plain film, CT, or MRI). The STSG has thus endeavored ton increase the reliability OF the PLC sub score. To tons this end, A of series OF of studies have been undertaken tons clearly DEFINE the principle of indicator OF PLC disruption on MRI. Thesis definition wants included in A revised classification system. This revised classification system is termed the Thoracolumbar Injury Classification and Severity Score (TLICS). Only the most severe (highest totally POINTS) injury morphology category is included into the scoring. Compression morphology garners 1 POINT, and additional POINT is assigned for burst on morphology. Three POINTS of acres assigned for A translational/rotational morphology and 4 POINTS for A distraction morphology. The descriptive "distraction" is only applied if there is objective imaging evidence OF distraction present. Scores OF the morphology subgroups acres emergency of additives if multiple morphologies of acres present. Studies of acres underway tons develop and validate this classification system. Controversy persists in management OF of thoracolumbar injuries. The TLISS clinical algorithm offers assessment OF injury stability and AIDS in making treatment decisions. The scale has shown adequate reliability between and within different specialties. Incoming goods show reliability and validity OF the TLISS scale across geographic boundaries, comparing US and non US surgeons. Differences between thesis broad geographic groups were subtle, with inter+ more rater reliability between groups similar tons reliability within groups. This suggests that the TLISS May help unifying clinical decision making in thoracolumbar trauma. The author(s) declare that they have NO competing interests. "style="vertical align:middle. margin-right:3pt "JR assembled cases for review and LED the manuscript preparation EFF place the manuscript. WELL participated into writing the and manuscript interpreting the results OF the reliability DATA. ACRE conceived OF and designed the study, and LED the development OF the TLISS. ML assisted in DATA analysis and manuscript preparation, including writing OF the methods section. JL LED DATA collection and analysis and assisted in manuscript preparation. Pa performed the literature review and assisted in manuscript preparation. JH which A more leader into the development OF the TLISS and wrote the discussion section OF the PAPERS. RR which A more leader into the development OF the TLISS and assisted in manuscript preparation. CB which A more leader into the development OF the TLISS and assisted in manuscript preparation. RG which A more leader into the development OF the TLISS and drove European participation in this project. The entire STSG participated into the evolution OF this classification system and served as case raters for this reliability study. All authors reviewed and approved OF the finally manuscript. The development OF the TLISS and TLICS of system which A collaborative EFF place by members OF the Spine trauma Study Group. This work which supported, in part, by on unrestricted educational and research grant by Medtronic Sofamor Danek, Memphis, TN. "style="vertical align:middle. margin-right:3pt ". Nonoperative treatment OF burst type thoracolumbar vertebra fractures: clinical and radiological results OF 29 patients. Wood K, butter man G, Mehbod A, Garvey T, Jhanjee R, Sechriest V, Butterman G. operational one compared with nonoperative treatment OF A thoracolumbar burst fracture without neurological deficit.[see comment][erratum appears in J Bone joint Surg to the Vaccaro ACRE, Zeiller sports club, Hulbert RJ, Anderson one Pa, Harris M, Hedlund R, Harrop J, Dvorak M, Wood K, Fehlings mg, Fisher C, Lehman RA Jr. The thoracolumbar injury severity score: A proposed treatment algorithm. Wood KB, Khanna G, Vaccaro ACRE, Arnold PM, Harris MT, Mehbod AA. Assessment OF two thoracolumbar fracture classification system as used by multiple surgeons. Vaccaro ACRE Lehman RA, Hurlbert RJ, Anderson one Pa, Harris M, Hedlund R, Harrop J, Dvorak M, Wood K, Fehlings mg, Fisher C, Zeiller sports club, Anderson one DG, Bono cm, stick GH, Brown AK, Kuklo T, Oner FC. A new classification OF of thoracolumbar injuries: The importance OF injury morphology, the integrity OF the posterior ligamentous complex, and neurologic status. The three column spine and its significance into the classification OF acute thoracolumbar spinal injuries. Cherkin DC, Deyo RA, Loeser JD, Bush T, Waddell G. Internationally comparison OF on bake surgery advice. Blauth M, Bastian L, Knop C, long U, Tusch G. [ inter+ more observer reliability into the classification OF thoraco lumbar spinal injuries ]. Harrop J Vaccaro ACRE, Hulbert RJ, Wilsey J, baron EM, Shaffrey C, Fisher C, Dvorak MF, Oner FC, Wood KB, Anand N, Anderson one DG, Lim M, Lee J, Bono cm, Arnold P, Fehlings mg. Irwin ZN Hilibrand A, Gustavel M, McLain R, Shaffer W, Myers M, glazier J, hard RA. Variation into surgical decision making for degenerative spinal disorders. Lee JY Vaccaro ACRE, Lim MR, Oner FC, Hulbert RJ, Hedlund R, Fehlings mg, Arnold P, Harrop J, Bono cm, Anderson one Pa, Anderson one DG, Harris MT, Brown AK, stick GH, baron EM. Thoracolumbar injury classification and severity score: A new paradigm for the treatment OF thoracolumbar spine trauma. Submitted ton journal OF Spinal Disorders and Techniques. Fractures, dislocations, and fracture dislocations OF the spine. Journal OF Bone &. joint Surgery - American volume. Magerl F Aebi M, Gertzbein SD, Harms J, Nazarian S. A comprehensive classification OF thoracic and of lumbar injuries. The load sharing classification OF spine fractures. Trend and geographic variation in major surgery for degenerative diseases OF the hip, knee, and spine. Advice OF advanced spinal imaging and spine surgery. Ashton cm, Petersen NJ, Souchek J, Menke TJ, Yu HJ, Pietz K, Eigenbrodt ML, Barbour G, Kizer KW, Wray NP. Geographic variation in utilization advice in veteran Affairs of hospital and clinics. The of veteran Affairs medical care system: hospital and clinic utilization statistics for 1994. Pedicle screw fixation in spinal disorders: A European view. World journal OF emergency surgery: WJES. Department OF Health and Human services

Im looking at you through the glass lyrics

Tribulations of Lyons A Vancouver - List of the last articles published on hellostephanie. Blog of girl: Jude-To pronounce Djoude. Beautiful known and less known mouths). , while returning, I had this song in the tete (has moments difficileuhs there, but in these moments, to have friends it is very utileuuh). Yesterday evening, I drank last glass with, which flew away this morning in France, finishing his academic year. The evening of yesterday thus etait particuliere. I said myself that today, it is him which leaves, soon Ca will be Ezra, and then another, and then one day, my visa will end. As much to say, that tiredness, and two beers helping, I sailed between the laughter and the few tears. I was to thus join it him and other French in a pub, I etais has the inn with my Australian, and those (finally especially Ezra) have decide to follow me to find the frenchies, which pleased very to me well on, I wish you a very good return in France, same if I know that Ca has being very difficult yesterday evening and this morning. I espere that all will occur well for you over there. Thank you hein, cheer, I quote it: "And benefits the max, Ca passes so much quickly". As I have then explain has Ezra, you start has to know somebody, well papoter, and hop., it is the kind of guy who accompanies back me until A my door has each end of evening, qqsoit the hour. That which holds you your umbrella under the rain. It is that which wants to go to dance every evening and sends sms to you to be on you will come. That which sees the small tear shining with the corner of the eyes and which comes to comfort you in the minute which follows. That which rubs you the back for you rechauffer whereas wears to him a tee-shirt. That which opens all the doors to you, which amene a wine bottle when you invite it has to eat to have less has to go after). It is the guy who wants to divide into sheets my French books after my courses to know what I made. It is the guy who enough in front of my grimaces, my imitations of the tramp has the wooden leg which tries to run (. But never nothing other (* * * hhgdasjh). Then not to melt in front of as much attention and gentiless, is necessary to have the heart well hangs, which is not any more my case. Ezra is the one who comes back in Australia in 10 days. Other photographs of evening CENSORED. if Ca, it is not soliciting for my blog Photo). Sunday, 1:20 PM, second aspirin, second coffee. But initially, I cuts to talk butt my so good goal "ouinnnn" weekend. Friday evening, I finish by ceder has the pressure of Friday evening (forcing), without too much difficulty well is necessary to acknowledge it, and join Charlotte etant of babysiiting), Alex and Laure drinking. the pub of my inn, and, eh eh, my band the Australian ones is it (sign that my decision not to leave risk to be given has later). Quickly, Ezra starts has to launch plays as if one needed Ca for drinking), by adding rules each time has. Bug, jai been able to teach them a trick, if it is not the class. Then, Ca becomes complicated when one starts really has to be. Especially when Guillaume us A tells the following day () which it had said all the evening "To swiiim" to the losers, whereas us, one said. Ca goes hein, one is enough foutu of me when I am arrivee has Vancouver) Bref, the frenchies do not finish returning, me I find itself embarquee by. You will never guess why) on Granville Street, the search for one has limps or there is not 1h of waiting, which is rather difficult follows us, the guy want that I translate because it does not speak English (Canadian who does not speak English, one will have all considering). his french canadian is really really hardware to understand with has big and really strange accent. Approximately, I do not bread large thing, and make large signs with the guy which require of me what he says ". With force to sail of a place has another, one finishes by. 3 hours later, after dance and pizza pie, I come back to my home, with Ezra, my offical bodyguard, and we speak til 5:00 AMNDT fraiche and pimpante to go to give my French course has mon.colombien government, je spends my time has to give it in the right way of the cours.(it speaks much English et.n' arrete not to invite me has evenings salsa."en-all-well-all-honor-hein", or has to propose to me to go to run with me come to the house, blah, I forget my french, I didnt speak french since has long time. Saturday evening, I meet her.to the.Beaver (again). It was her birthday tuesday, so I come with chocolate for her. Same the tablee or almost that day before. Note: To think has to make abdos Tous.les.jours). Pi a friend of Clement has arrived, Corinne., it reads my blog for approximately two months (by seeking blogs on Vancouver, it is arrivee at home), I know to it his depuis.une week, and it had connait Clement for 6 months. Pi after, has there two other French who arrives and I had earlier cross them in Stanley Park 3 weeks. , Ca becomes when same odd this evening (and I do not say Ca because of beer, and owing to the fact that all English are spoken whereas there is almost only of French). To finish, the coloc of Clem' is able, and while papotant with it, I speak to him about my Colombian trainee. And I give it to you in the thousand, it bump with him. In short, any Ca for saying that it is impossible to return in least the nightclub without waiting 2 hours (France also misses me in these moments it). Return has the Beaver box, Ezra returns from the job, and joint has us, thus forcant us has to speak English. Anyway, I really roofing stone my french, and I cant manages speaking french (and maybe, this time, it' S because of the beer too). One ends up finding a pub or one can finally enter. The music is a true happiness for the ears: of the old men. and nobody knows here that in Mardi-Gras, has Tuesday there (. Bodyguard oblige).et decouvre my coloc still upright, well. And veiled us has pleurnicher on our fate of celibataire (and it sucks because He leaves Canada in two weeks, and I will really miss him. My coloc, tell it, I that it has flashe on a guy, Marie - thus has another guy -, and that it is degoute). after to have slept 1h30 the night preceding) photo pourrite, dedicace has Julien and Caro) As me pointed out it my ptite sister, Ca a.fait one month Thursday that I left (. or I have firm the door of my appart, towards 2h of the morning. I had almost not slept the preceding night, and I had master key the day in bags and paperboards, between tears and phone calls of the friends. Evening meal in the parents, odd. I etais retournee at home to finish all buckling, with the impression that I will never arrive there (moreover I left while forgetting full with things has to make, AND my running Any Solomon Ground. The same more force to answer tlephone.tellement I chouinais. I took Gribouille, and I have it amene at Christophe and its chery, effondree (. or presque), il have fallu.tout eteindre, and to leave. The city etait in the fog, it etait so strange, as if I left the city like a robber. The following day, my parents have me accompagnee A. Plus energy to answer, concentree on the fact of not crying while saying goodbye to the parents. One took a ptit dej has the airport (kind click-clac-click-clac, the hour arrives, I cannot move back any more) and it was the hour. I did not arretais to tell me "Bug, this time Ca is there, this time Ca is there. A few minutes later, I saw the face of my parents disparaitre derriere the counters, a girl cries while looking by the port-hole. I have so much cry the last days that my eyes are dry, and especially, it is almost a moral "relief", the bide complement ties but the brilliant eyes of exitation. My visa is aggrafe on my passport, thank you goodbye. But why they is if lourdeuuh (. When I release a bag, the other falls and vice versa. Finally, I join the exit, finds the shuttle which goes in centre town and crosses allemande PVTiste who goes has the same inn that me. And then veiled, I cross the city in the bus, it rained, I am more sleepy. I do not include/understand large thing with the speech of reception of the injury of the AJ, excludes the fact that there are pancakes gratos the morning, history to see a little has what resembles the city, and to adapt me my new time zone has. For my.second night in the city., the first girl I puts here, my first friend in Vancouver), invited me to join her and her friends to the Beaver, the Hostel Pub. Ashton, Ezra, Coleen, Alin, Georgia. It was last month, and the same are always here, Ezra, Coleen, Shelley, Ashton not far. Yesterday night, I was to the hostel again, have often, with the same. I remember the first night, I wanted to go to bed early, and it was 3:00 Pm when I slept. I remember to cuts try to speak english goal to not really understand what they were saying. Ca passes quickly, but what it is well (. And bug, I still do not have eats of good goat's milk cheese (I acknowledge, I think of cracking tomorrow has Granville Market, avec a part of under my first particular French course). Cut fun goal Come Back Today, I wanted to speak about one month ago. Because for the premiere time yesterday, I had the impression to find, those of my equilibre, a part of my cardinal points. Good, it misses the family and the friends (. But I have (re)trouve a little what is in oneself important and necessary for really integrer and to benefit from this adventure has bottom in a new country, a new culture, and "a new" language (because, quoi which one can say, who one maitrise or not the language of the country, Ca empeche not to be the etranger, not to seize all the nuances, etc. For the premiere time this week, I left at home by having the impression to be at home and not a tourist. Not that until A now, I did not feel at home, quite to the contrary, but I do not know. I left and I am say the same things that I said myself has Lyon: "Good, this morning, is necessary that I go has the bank" (finally, I rather said "Pu **** of me**eeuh"), "Hold, the player of failure it is maintaining in my school yesterday evening (mm good the schedules, end of the course 21h30, veiled what is to arrive in full year). Job thus a part of the day, coupee of a jogging malgre a foutu wind, which, oddly (. but good I until A me paindre would not run at the edge of the Pacific), and with the return, That flagstone. whereas I etais.preparee during all the outward journey has what this soit.trop easy with the return. This first course is "well" passes. Lastly, if one puts of dimension the fact that CD of ecoute, support has ALL the course, did not function, and that I have thus to improvise, in English considering they are quasi debutants. Fortunately, has the pause, I have reussi has to put the hand on Cd which functioned. And my 13 adult trainees etaient sympas bloody (and I do not say Ca because they have finds my English "pretty good" - however I had not drunk Note for later: To think has to use has all sauces, Ca seems to be a word pretty well). Fortunately also that Profs are super sympas and have me conseillee. The trick etant nutcase that one of the trainees bump with French with whom I drank glass last week (a researcher in medicine, cousin of a neighbor-quasi-of-the-family of my large parents which drinks glass has my inn for his birthday, but meanwhile I recois a texto from which awaits me to go to dance. Already in France, I adored the plans of derniere minute, then here, you think well. And embarquee veiled me on Granville Street has the search for one of the multiples "limp" (their limp move has 10h PM and close has 1h AM) or the drinks are has 2$ but the entree not too expensive. and capoeiriste).en training course here for six months has invited me to join me and to benefit from drinks has 2$ (. Clement sets out again the next week to finish its year in France Not (. but it is true, with which I will make will capoeira on the beach this ete. But Clem perhaps will return (hin hin).pask its limps him A proposes a TDCI with one mechant wages (which you cannot refuse hein. While leaving, small stage with the pizzaiolo of the corner or we eat two shares of pizza pie for 2$ (. Ezra, certifying to me that the streets are not sour for a girl alone (whereas, mom, Vancouver is the sourest city of America), accompanies back me until A at home by holding my umbrella (salete, goes) that if I include/understand it so well now, it because it speaks more gently, is also done gestures and all. It announces aussi.qu' to me it read my small word for him of English, that promised, it will try to learn French (You will try to lean french.), and that it is necessary that I come to see it in Australia (I will not forget you cuts invited me in Australia. As the ridiculous one does not kill, I thus go retenter the ptit end of English for him. So thank U again, you' Re really has great Guy, you know that. Any Ca for saying that full different people are met, who leave and who return (or not), and it is also Ca the richness of this immigration. A good cake with almonds and the chocolate. Sherif, Make me sound the gong of the house here (it is the fete) the tele, it is a little as a great adventure, a dive in our sympathiques years of adolescence, a surprise has each zapette, of the moments to laugh which you would not have same step dares esperer in your worst. and very full with chains (around fifty). Except that while zappant, I realized that I had several times same the chains, on different channels, hyper practical the morning, OK, y.a of the flashes infos very often, OK, has chains there or y has almost that Si is to announce that the rain returns, that the aviary influenza has attack Europe, and that the Frenchwomen lost in boarder cross-country race (moreover, trick enough nutcase, it is that I saw the race of a Frenchwoman, Julie Pomagaski, against who I had surfe in championships of France has qqs annes there. My coloc etaitsur the bottom, me also when I saw that it had made the OJ. Sex and the city, Friends, Desperate Housewives. it is cut all les.10 mn by. The worst etant than they balance a page of pub has the end, BEFORE the generique one. Being gives that I do not like the pubs (which are in more hyper but really. Except that then, time that I find my chains on the 55, series A already starts again and the spot of following pub is already arrives. Result, I had pass the evenings has zapper to find my series. As much to say that I have arrete zapper. I am zappeuse compulsive with the least spot of pub). chains with full of old films full with chains with an old film. Y has chains which diffuses good old men films with Cary Grant, Audrey Hephburn, etc. Pi there so full with chains which diffuses 25 times I adore, but good god what it is kitch), I pass from there and from best. In Las Vegas, Miami has, has St Etienne, ah not that it does not exist one has especially also fantastic series which I had almost oubliees. Pure moments televisuels, such as the series well americaine or they speaks about God 24/24), or. Y has same one of the principal actors - not the beautiful John Stamos- who is master key in One Man Show here has Vancouver), or. Rosane (with Rosane Barr you recall), or hold you well. When I think that I have leave in France Mac Gyver and the cruising has fun no matter what, what can be worse than Sherif Fais me fear my coloc likes to buy Star). who sells his DVD of Dance has the tele. Carnard-Savage-with-dela-of-the-mountain-Whistler the meeting tupperwouare, the singer of will opera and the poet (pouet). What the hell is wrong with this Guy. Heart frainche goal goes spik inglich. Lemon juice, the norvegien and my basin of traviole Carnard-Savage-with-dela-of-the-mountain-Whistler Carnard-Savage-with-dela-of-the-mountain-Whistler.

What area code is 866

Bell Canada makes available the num?que T?phonie service on Internet. See the ic?s Communiqu?de document-case presses by cat?rie All the communiqu?par date Commande mat?el on the company Bell Canada makes available the num?que T?phonie service on Internet MONTREAL, March 30, 2005 -- Bell Canada today has annonc?ujourd' that it made available T?phonie the num?que service from Bell, a service of t?phonie according to protocol Internet (VoIP), with the consumers of three. This advertisement follows several months of technical tests of. The service will be offered to the consumers of Qu?c. T?phonie the num?que service of Bell is an application Internet which makes it possible to the consumers to make calls by means of any connection Internet high speed existing, whatever the supplier of service DSL. Offered?rix fixes, the new service counts many fonctionnalit? like personalization on line of the service, the choice of r?onaux codes, the r?ption of vocal messages by courriel and the automatic reference?lu?ainsi that interurban the illimit?installer him-m? service and to use its apparatuses t?phonic. The case of d?rrage contains all the mat?el n?ssaire. "With T?phonie the num?que service of Bell, we put services Internet of the next g?ration?a port?des consuming," said Ron Close, pr?dent - service VoIP, Bell Canada. "As the service is offered on a connection high speed, by c?e or DSL, the consumers profit. T?phonie the num?que service of Bell is offered?rois contractual monthly prices, according to the plan of interurban illimit?hoisi: 38 $ (calls?' int?or of the province), 40 $ (calls everywhere in Canada) and 45 $ (calls All the functions?lu? are included/understood. There are not expenses of activation or contract and the first. Functions included/understood in T?phonie the num?que service of Bell: - Reference voice messaging?ourriel - are your vocal messages automatically achemin??otre addresses courriel - Transf?bilit?u service - your service and your num? Do num?que T?phonie follow you everywhere in the world - automatic Reference Plus - convey the totalit?u a part of your num? ?a house and your num? with the country cottage, so that they do sound in - popular Functions - bill-poster, call on standby, voice messaging, filtering of calls, conf?nce?rois - Service to measures on line - personalize the functions of your service in any time?' assistance of a Web site - Choice of r?onaux codes - choose a code r?onal among 23 cities everywhere in Canada, whatever the o?ous city live - Functions suppl?ntaires - add a num? room of one of the 23 Canadian cities for only 4 $ per month by num? and organize t?phonic conf?nces for only 4 $ per month. The consumers of Qu?c, Trois-Rivi?s and Sherbrooke can subscribe while passing to the store Espace Bell of their localit?u while composing. To know some more about this service, visit the site. Bell Canada, the Canadian leader of the communications, r?nd to the needs for connectivit?es customers of r?dence and businesses in their offering services of transmission of the voice and donn? on wire and without wire, of the local and interurban services t?phonic, the services of acc??nternet high speed and without wire, of the IP/large services bandages, the solutions of?ctronic businesses and the services of t?vision per satellite. Is Canada the propri? exclusive of ECB Inc. Information: Nathalie Moreau, Relations with the m?as, Bell Canada. To go?' index of the communiqu?de press.

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. Ils contiennent de ce fait DES inexactitudes vis?is DES documents originaux ET n' ont pas de valeur l?le. Cardiovascular disease Cardiovascular disease (CVD) still remains the leading causes of death and disability in the western world. The National Cholesterol Education Program (NCEP) identified elevated LDL (low density lipoprotein) as to major causes of CVD (JAMA 2001. 285 (19), 2486). The World Health Organization (WHO) has identified high cholesterol as the leading risk factor for CVD in the developed world. To decrease in LDL of 10% in men is associated with to decrease in the risk of cardiovascular disease by 50% at the age of 40, by 40% at 50, by 30% at 60, by 20% at 70 and over (BMJ 1994.308:367-372). Cholesterol although needed in the body can injure blood vessels and causes heart attacks and stroke when present in excessive amounts. The body needs cholesterol for digesting dietary fats, making hormones, building cell walls, and other important processes. Lipoproteins to are particles that carry lipids and proteins in the blood and gut. There to are five classes of lipoproteins:. Chylomicrons, which to are mostly triglycerides and to are secreted from the gut. Very low-density lipoprotein (VLDL), which to are mostly triglyceride and to are secreted from the liver and gut. Intermediate-density lipoprotein (IDL), which to are mostly triglyceride and cholesterol and to are secreted from the liver. Low-density lipoprotein (LDL), which to are mostly cholesterol and to are secreted from the liver. High-density lipoprotein (HDL), which to are mostly protein and to are secreted from the liver and gut. The higher the LDL cholesterol concentration in the blood, the greater the heart disease risk. HDL is '.good'. cholesterol and helps prevent to cholesterol buildup in blood vessels. Low HDL levels increase heart disease risk. Too much of this circulating cholesterol can injure arteries which can lead to accumulation of cholesterol-laden ".plaque". in vessel linings, to condition called atherosclerosis. The development of atherosclerotic lesions requires to complex interplay between mononuclear cells, endothelium, vascular smooth muscle, growth factors, and cytokines (Ross, 1999). Several studies have demonstrated localized expression of leukocyte adhesion molecules in atherosclerotic lesions and plaques. They appear to regulate different stages of leukocyte migration at inflammatory sites in to fines-step process (Springer, 1994). Members of the immunoglobulin superfamily of endothelial adhesion molecules, vascular cell adhesion molecule (VCAM-I) and intercellular cell adhesion molecule (ICAM-I). strongly participate in leukocyte adhesion to the endothelium. VCAM-I is highly expressed on endothelia prone to develop atherosclerosis in such atherosclerotic models as apoE mice, mice LDL receptor- deficient (LDLR) mice, and rabbits fed with an atherogenic diet (Iiyama ET to. ICAM-I is expressed strongly on the endothelium overlying atheromatous plaque in human coronary and carotid arteries (DeGraba, 1997), hypercholesterolaemic rabbits (Iiyama ET al., 1999), although it is expressed in virtually all endothelial cells. One of the most significant advances in drug therapy during the twentieth century was the development of the statin class of drugs. In addition, to growing body of evidence suggests that statins exert beneficial vascular effects that are independent of their cholesterol lowering potencies (Farmer, 2000. LaRosa, 2001). Cholesterol levels may be decreased by several materials. These includes statins, sterol/stanol, bile acid sequestrants, CETP (cholesteryl ester transfer protein) inhibitors, fibrates, niacin, dietary fibers etc. Statins target hepatocytes and inhibit HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl coenzyme To reductase, E.34), the enzyme that converts HMG-CoA into mevalonic acid, to cholesterol precursor. These The change in conformation at the active situated makes drugs very effective and specific. All statins veteran LDL cholesterol non-linearly, dose-dependent, and after administration of to single daily dose. Efficacy on triglyceride reduction parallels LDL cholesterol reduction. Statins have to modest effect on HDL increase, and not influence on lipoprotein(s) concentration. Plant sterols to are poorly absorbed in the registers (0,3%) is even lower (for comparison, cholesterol absorption ranges between 35 and 70%). Vice Plant stanols may also lower plant sterol absorption and pours. As merely esterified sterols to are incorporated into chylomicrons, absorption of the unesterified plant sterols and stanols is consequently low. Different mechanisms have been suggested to explain the cholesterol-lowering activity of plant sterols and stanols. Firstly, plant sterols or stanols may displace cholesterol from mixed micelles, because they to are more hydrophobic than cholesterol. This replacement causes to reduction of micellar cholesterol concentrations and consequently lowers cholesterol absorption. Furthermore, plant sterols or stanols might veteran the esterification installments of cholesterol in the enterocyte and consequently the amount of cholesterol excreted via the. The effects of plant stanols on cholesterol absorption continuous for at least several hours after ingestion. In response to the decreased cholesterol absorption, cholesterol synthesis increases. Also, LDL receptor mRNA and protein expression increases. This will not only increase clearance of LDL, but also of IDL. The higher LDL receptor expression and the higher endogenous cholesterol synthesis together result in an average reduction of LDL cholesterol of up to 14%. The decrease of total serum cholesterol is completely accounted for by to reduction in LDL. Plant sterols and stanols have not effect on triacylglycerol or HDL cholesterol levels. In summary, stanols and/or sterols result in an LDL reduction of between 9 to 14%. (iii) Bile acid sequestrants (BASs) Bile acid sequestrants (BASs) to were the first class of antihyperlipidemic drugs developed to lower LDL cholesterol levels. Conversely, the disturbance of enterohepatic recirculation activates this enzyme, leading to amplified conversion of intracellular cholesterol to bile acids. The direct effect is to decrease in intracellular cholesterol stores that subsequently leads to to lowering of LDL cholesterol. Despite this increase in cholesterol synthesis, however, total cholesterol levels I give not. increase because of the rapid shunting of cholesterol into the bile acid synthesis pathway. The activation of HMGCoA reductase may explain the success of combination therapy with BASs and HMG-CoA reductase inhibitors for primary hypercholesterolemia. In addition to decreasing total cholesterol and LDL cholesterol, BASs can causes an undesirable increase in serum triglycerides. The increase is triggered by activation of phosphatidic acid phosphatase, an enzyme responsible for the conversion of glycerol phosphate to either triglycerides or phospholipids. Phosphatidic acid phosphatase is suppressed under the normal conditions of to functional enterohepatic recirculation system. Because of their potential to elevated serum triglycerides, BASs should not be used as monotherapy for patients with increased triglyceride levels. The triglyceride-elevating effects of BASs may be countered by the addition of agents known to decrease triglyceride synthesis, such as fibric acid derivatives (i., fenofibrate and gemfibrozil) and nicotinic acid. There to are many examples of BASs but the two main commercially available ones to are Welchol and chitosan. These generally lead to an LDL reduction of about 10%. During the last couple of decades, much attention has been given to the role of dietary fibres in the control of lipid and lipoprotein metabolism. Dietary fibres includes to variety of plant substances, mainly nonstarch polysaccharides and lignins, which to are resistant to digestion by digestive enzymes. They can be classified into two groups based on water solubility. Soluble fibres may lower plasma total cholesterol by to specific effect on LDL cholesterol. HDL cholesterol or triacylglycerol concentrations to are in general not affected. Several mechanisms of action for the hypocholesterolemic effect of soluble fibres have been suggested that may depend on the type of fibers. This layer may act as to physical barrier to veteran the absorption of nutrients and bile acids. Increased intestinal contents supernatant viscosity is highly correlated with reduced plasma and liver cholesterol and reductions in cholesterol absorption in hamsters. Furthermore, soluble fibres may veteran the installments of glucoses absorption, leading to to lower glycemic response and lower insulin concentrations. This latter may result in to reduced hepatic cholesterol synthesis. There to are many examples of high viscosity soluble fibres. The main commercially available soluble fibres to are psyllium, glucomannan and β.-glucan. These generally lead to an LDL reduction of about 6 to 7%. (v) Cholesterol ester transfer protein (CETP) inhibitors The marked increase in HDL associated with human deficiency of cholesteryl ester transfer protein (CETP) has suggested CETP inhibition as to means of elevating HDL. Recently, to new CETP inhibitor, Torcetrapib, was tested in two studies in human subjects. In the first, the effect of CETP inhibition on plasma HDL levels was studied in healthy subjects. With the above treatment, plasma LDL decreased by 42%, HDL-C increased by 91%, as did apo To the and apo and, by 27 and 66%, respectively. In the second study, Torcetrapib was given to 19 normal subjects with low plasma HDL-C levels (<.40 mg/dL), 9 of whom received atorvastatin, 20 mg/day (Brousseau ET to. In subjects who received only 120 mg/day Torcetrapib for 4 weeks, HDL was increased by 46%. in those treated also with atorvastatin, the increase was 61%. To much higher laughed in HDL- C, 106%, occurred when the drug was given twice ones daily, but not atorvastatin. In six subjects treated with the two drugs, to there was also to 17% decrease in LDL-C. In addition, Torcetrapib decreased the levels of small dense LDL and increased the concentration of large HDL to values seen in subjects with normolipidemia. Ezetimibe is to US Food and Drug Administration-approved drug that targets the absorption of cholesterol in the registers some. The identification of this drug has also led to the elucidation of the dietary cholesterol receptor. It has to very favourable side-effect profile, as well as to lack of drug-drug interactions. Nicotinic acid (niacin) lowers total and LDL cholesterol and raises HDL cholesterol. Fibric acid derivatives such as gemfibrozil and fenofibrate can also increase HDL levels, but to are used mainly to lower triglycerides. Type 2 diabetes mellitus is two to to combination of defective insulin secretion and defective responsiveness to insulin (often termed reduced insulin sensitivity). In early stages the predominant abnormality is reduced insulin sensitivity, characterized by elevated levels of insulin in the blood. The initial defect of insulin secretion is subtle and initially involves only the earliest phase of insulin secretion. The complications to are less common and less strict in people who have well-controlled blood sugar levels. The second component may be selected from to sterol, an esterified and/or hydrogenated sterol, to stanol and to statin. Preferably, the second component may comprise to sterol. Alternatively, the second component maybe to satin such as to 3-Hydroxy-3- methylglutaryl CoA (HMG CoA) reductase inhibitor. The composition may be suitable for oral administration. Preferably, the composition may be in the form of to tablet, pellet, caps, granule or to microsphere. Alternatively, the composition may be in to form suitable for incorporation into foods, beverages, nutraceutical or pharmaceuticals. The first component may be derived from to starch, celluloses or gum, or is of microbial origin. Preferably, the first component may comprise to microdispersed derivative celluloses or thereof. The first component may be prepared by partial or complete hydrolysis and neutralisation of to WAGE containing material. The first component may interact with biomolecules in the fluid medium of the gastrointestinal tract. The composition may further comprise at least one biocompatible biologically active substance. The composition may further comprise at least one biologically acceptable adjuvant such as to pharmaceutically active adjuvant. The adjuvant maybe an antilipemic agent such as to phospholipid. For example in patients with Type 2 Diabetes Mellitus. The medicament maybe for oral administration. For example, the medicament maybe in the form of to tablet, pellet, caps, granule or to microsphere. Alternatively, the medicament may be in to form suitable for incorporation into foods, beverages, nutraceutical and pharmaceuticals. The polyanhydroglucuronic acid, to salt thereof, copolymer thereof and an intermolecular complex thereof may be derived from to starch, celluloses or gum, or may be of microbial origin. SATISFIED The may comprise to microdispersed derivative celluloses or thereof. SATISFIED The may be prepared by partial or complete hydrolysis and neutralisation of to WAGE containing material. SATISFIED The may interact with biomolecules in the fluid medium of the gastrointestinal tract. The medicament may further comprise an antilipemic agent. For example, the antilipemic agent may be to sterol, stanol, statin, esterified and/or hydrogenated sterol. The statin may be to 3-Hydroxy-3-methylglutaryl CoA (HMG CoA) reductase inhibitor. The medicament may includes at least one biocompatible biologically active substance. The medicament may includes at least one biologically acceptable adjuvant such as to pharmaceutically active adjuvant. The adjuvant may be an antilipemic agent such as to phospholipid. Preferably the polyanhydroglucuronic acid and salt thereof may contain in their polymeric chain at most 0. The molecular mass of the polymeric chain of the polyanhydroglucuronic acid and salt thereof may be from about the X. The molecular mass of the polymeric chain of the anionic component may range from about 5 X 10. The content of carboxyl groups may be in the range of from about 12 to about 26 percent by weight, at least 95 percent of these groups being uronic groups. The polyanhydroglucuronic acid and salt thereof may contain at most 1 percent by weight of carbonyl groups. Preferably, each carbonyl group may be an intra- or intermolecular 2,6 or 3,6 hemiacetal, to 2,4-hemialdal or to C2-C3 aldehyde. The biocompatible intermolecular polymer complex may be to complex of: an anionic component comprising polyanhydroglucuronic acid or salt, which is that of to partially or completely hydrolysed and oxidative-environment hydrolysed polyanhydroglucuronic acid containing material. and protein cationic component comprising not delineating or branched natural, seeds-synthetic or synthetic oligomer or polymer. Preferably, at least 5% of the basic structural units of the anionic component may be glucuronic acid. acrylamide, butylacrylate, maleicanhydride and methylmethacrylate. Preferably the cationic component may be to cationised natural polysaccharide. The polysaccharide may be to starch, celluloses or gum. Preferably the gum may be guargumhydroxypropyltriammonium chloride. The cationic component may be to synthetic or seeds-synthetic polyamino acid. For example the cationic component may be to member selected from the group consisting of polylysin, polyarginin and. Preferably the cationic component may be to synthetic anti-fibrinolytic such as hexadimethrindibromide. The cationic component may be an aminoglucane or derivative thereof such as to fractionated chitin or its de-acetylated derivative chitosan. Alternatively, the aminoglucane may be of microbial origin or is isolated from an arthropod shell. The invention in particular involves the use of polyanhydroglucuronic acids, salts and intermolecular complexes (IMC) thereof. The term polyanhydroglucuronic acid, salts and IMCs thereof as used herein also includes copolymers thereof, especially with anhydroglucose. These as to whole to are hereinafter referred to as SATISFIED specification SATISFIED is also referred to as microdispersed oxidised celluloses (MDOC) available from Alltracel Pharma Limited. CS 242920, CS 292723, GB 2314840, but notably WO98/33822 describe particular polyanhydroglucuronic acids and salts thereof and to method of preparing such compounds. These aldehyde and ketone impurities have to fundamental influence on the stability of the polyanhydroglucuronic acid (SATISFIED) product. To stable SATISFIED product with to reduced degree of crystallinity and to high degree of purity in to microdispersed form is produced. WO00/05269 describes particular intermolecular complexes (IMCs) of SATISFIED. SATISFIED IMCs of in particular includes those referred to in WO00/05269, the to entire contents of which is incorporated herein by reference. The term ".non-protein". is intended to distinguish from what the applicants understand the commonly used definition in biochemistry of ".protein". to be. IUPAC Recommendations 1983: Nomenclatures and Symbolism for Amino Acids and Peptides). Proteins differ from polypeptides in having higher molecular weights (by convention over 10,000) and more complex structure. The cationic components of the complexes described in the invention includes Inter alia small molecular weight peptides and aminoglycans. These components would be commonly understood to have to low molecular weight typically less than 5,000. For example the frozen some used in the invention is suitably hydrolysed which results in to reduction of the molecular weight. The frozen some used in the invention is described as to peptide which to person skilled in the art would take to infer to compound of low molecular weight. The AIN-93 synthetic diet (Journal of Nutrition vl23, 1943-44 (1993)) consists essentially of the ingredients listed in Table 1 below. More The invention will be clearly understood from the following description thereof with reference to the accompanying Figures, in which: -. 2 shows the immunohistochemical staining of endothelial expression of an inflammatory marker ICAM-I in (a) to control group, (b) to simvistatin group, (c) an atorvastatin group and (d) an oxidized celluloses (MDOC) group. There is strong endothelial expression in control animals (a) and weaker expression in simvastatin (b), atorvastatin (c) and MDOC (d) treated animals. The ICAM-I expression in atorvastatin treated animals (c) is visible in only to few endothelial cells (arrows). 3 shows the immunohistochemical staining of endothelial expression of an inflammatory marker VCAM-I in To) to control group, (b) to simvistatin group, (c) an atorvastatin group and (d) an oxidized celluloses (MDOC) group. There is strong endothelial expression in control animals (a) and decreased expression in simvastatin (b), atorvastatin (c) and MDOC (d) treated animals. Very weak endothelial expression of VCAM-I (arrows) was detected in the atorvastatin (c) and MDOC group (d). 4 is to bar chart showing the percentage of activated endothelial cells in both the aortic root and the aortic arch. The expression of the inflammatory marker VCAM-I is significantly decreased in atorvastatin and mice MDOC treated in. Moreover, atorvastatin significantly reduced expression. -- X of the inflammatory marker ICAM-I in comparison to the control group. Fig 5 is to bar chart showing the percentage of activated endothelial cells in control, atorvastatin and MDOC groups. 6 is to linens graph showing weight gain during the course of to combination therapy study for control groups and treatment groups. 7 is to bar chart showing the effect of dietary supplementation in to combination treatment study of to high cholesterol diet (HCD) with 1% oxidised celluloses (OC) MDOC and 0,5% sterol (w/w) on the serum LDL cholesterol concentrations in rats (n=20/gp) fed these diets. 8 is to bar chart showing the effect of dietary supplementation in to combination treatment study of to high cholesterol diet (HCD) with 1% oxidised celluloses (OC) MDOC and 0,5% sterol (w/w) on the serum total cholesterol concentrations in rats (n=20/gp) fed these diets. 10 is to bar chart showing the effect of the dietary supplementation of HCD with 1% and 5% MDOC (w/w) on the serum glucoses concentrations in rats (n=10/gp) fed these diets. Preferably the oxidised polysaccharide material is in the form of biocompatible anionic polyanhydroglucuronic acid (SATISFIED), salt or intermolecular complex (IMC) thereof. IMCs to are also formed for example with gelatin or peptides of hydrolysed collagen, but also with blood proteins or aminoglycans as described in WO00/05269. The salts and IMCs formed to are dependent on the hydrolysis conditions and types of salt, base and /or the mixtures used. In to particularly preferred embodiment the polysaccharide material is polyanhydroglucuronic acid, biocompatible salts thereof, copolymers thereof or to biocompatible intermolecular complex polymer thereof. Preferably the oxidised polysaccharide is derived from celluloses, starch, or gum, or is of microbial origin. Similar to hyaluronic acid (HAS), the SATISFIED displays reducing ability in to biological environment, yet with to higher assimilable organic carbon (AOC) value. SATISFIED They also display to higher osmolality than simple salts (such as Na salt). In addition the behaviour of the atherogenic index of plasma (AIP), (Dobiasova M. These indices to are currently considered as the most sensitive indicators of the profile plasma atherogeny. The parameter proved highly significant in terms of absolute differences and was significantly reduced after the first phase of SATISFIED administration. To further surprising effect was the markedly favourable effect of SATISFIED in contrast to lactose used as placebo on glycaemia and HbAIc values. reduction of glycaemic response may lead to reduction of insulin production and thereby to to decrease in hepatic cholesterol synthesis. These results to were however statistically insignificant. SATISFIED The results clearly indicated the potential favourable effect of and derh'.atives thereof on. the values of lipid and saccharide management in an organism. Similar cholesterol management results to were found in pre-clinical testing. SATISFIED Biochemical analysis showed treatment resulted in to very mild and insignificant lowering of total serum cholesterol in mice in comparison to the control group. Endothelial expression of VCAM-I in the aorta significantly decreased in WAGE (MDOC) treated mice when compared to non-treated mice. SATISFIED This potential anti-inflammatory effect may be related to the mild hypolipidemic effect of. This reduces the potential risks to the subject compared with other types of antilipemic remedies. The composition of the present invention may be used as an effective agent to lower serum cholesterol in animals, particularly humans. 1) Dairy Products—. such as cheeses, butter, milk and other dairy beverages, spreads and dairy mixes, ice cream and yoghurt. 2) Fat-Based Products—.such as margarines, spreads, mayonnaise, shortenings and dressings. 3) Cereal-Based Products—. comprising grains (for example, bread and pastas) however processed. 4) Confectionaries—. such as chocolate, candies, chewing gum, desserts, non-dairy toppings, sorbets, icings and other fillings. 6) Miscellaneous Products—.including eggs, processed foods such as soups, pre-prepared paste sauces, pre-formed meals and the like. Alternatively, the composition may be applied directly onto to food or into to beverage by the consumer prior to ingestion. Example To - Preparation of Polymer Complexes Materials: long-fibers cotton—.medicinal cotton wool oxidised by NxOy (proprietary). C6OOH 18. Neratovice) N-HANCE 3000 guargumhydroxypropyltriammoniumchloride (Aqualon—. Hercules). Procedures: 30 g of N-HANCE 3000 to were placed into to 5 1 beaker and 3 1 of demineralised water 2. Contents of the beaker to were intensely stirred for 30 minutes. The pH value was adjusted to less than 4,5 by addition of an acetic acid solution leading to to viscosity laughed grade to were added and the contents heated up to to temperatures of 50. On dissolution of the calcium chloride the stirring was interrupted and 2,7 kg of the raw oxidised cotton wool to were introduced. The mixer was closed and the contents to were agitated for 120 seconds. Then the pH value of the contents was adjusted by addition of to 20% solution of Na2CO3 to 6-6. The fibers suspension was slowly agitated for 10 minutes. Then the pH value was readjusted to 4,0 and the prepared viscous solution of N-HANCE 3000 was introduced. The contents of the mixer to were stirred intensely for 30 seconds. Subsequently 60 1 of synthetic rectified ethanol cone. 98% to were introduced into the mixer. After another 15 seconds from adding the ethanol the contents of the mixer to were transferred onto to vibrating screen, and the supernatant. The filtration cake was redispersed in the mixer in 60 1 of to 18 mixture of 1 of synthetic rectified ethanol cone. The fibers suspension was filtered again on the vibrating screen. The isolated material thus prepared may further servants to preseems final products of the nonwoven type via to wet or dry process. Example B - Preparation of Polymer Complexes (IMC-MDOC) Materials: oxidised short-fibers cotton (Linters - Temming) (proprietary) C6OOH 16. Neratovice). redistilled water (PhBs 1997). ethanol, synthetic rectified cone. Equipment: turbostirrer: ULTRA TURAX (Janke-Kunkel) sulphonation flask 1 1 heater 1,5 kW laboratory centrifuges: 4000 rpm thermostated water bath pH meter SMALL glass thermometer rotary vacuum dryer or hot-air dryer. Into to 1 1 sulphonation flask equipped with to turbostirrer and to heater, 400 mililiter of redistilled H2O to were placed, and 8 g of NaOH to were added. On dissolution, 50 g of oxidised Linters to were added, the contents to were heated up to 70°.C and the stirring intensity set to to maximum. After 20 minutes, 40 g of 30% H2O2 to were added into the flask, temperatures was increased to 85°.C, and maintained for another 10 minutes. The contents to were then cooled down to 50°.C on to water bath and frosted of solution (10 g of frozen some in 70 g of redistilled H20) warmed up to 50°.C was added to the hydrolysate. The temperatures was decreased to 25-30°.C and the pH of the system was checked and adjusted to to value of 6. Subsequently, 626 mililiter of synthetic rectified ethanol cone. 98% to were added gradually under intense stirring. The suspension of IMC thus formed was isolated using to laboratory centrifuges. The supernatant liquid was filtered away and the cake was redispersed into 250 mililiter of 50% ethanol. 98% and let to stay for 4 hours. It was then centrifuged again, redispersed into 99,9% isopropanol, and let to stay for to minimum of 10 hours at. The gel formed was centrifuged again and the product was dried in to rotary vacuum dryer or to hot-air dryer. The product can be used, for instance, for microembolisation, for preparation of haemostatic dusting powders, for manufacture of polymer drugs, and based on cytostatics, or for preparation of spheric particles for macroembolisation. Example C - Preparation of Tablets and Pellets from MDOC (Microdispersed Oxidised Celluloses) Materials: MDOC (SATISFIED CaTNa salt of), particle size 0.m, specific surface area 86 m2/g, COOH group content 22. Equipment: tabletting machine (KORSCH EK 0, Berlin) 100 g of MDOC to were introduced into the tabletting machine. The tabletting force was set at to value of 5 kN. The tablets prepared to were smooth and cohesive and had to weight of 0. Disintegration installments of the tablets in to you go up of it Fl/1 was 15 minutes at 20°.C, and 8 minutes at 37°.C. To patient aged 55, displaying an increased cholesterol content in blood was treated by MDOC tablets administered orally for 50 days, at to dose of 6 tablets daily. After the treatment both LDL content and total cholesterol content to were significantly reduced. Blood analysis: before treatment after treatment. Example and - Preparation of Tablets and Pellets from IMC-MDOC Complex Material: oxidised short-fibers cotton (Linters - Temming) (proprietary). Neratovice) redistilled water (PhBs 1997) ethanol, synthetic rectified cone. Neratovice) frosted of (PhBs 1997) Equipment: turbostirrer: ULTRA TURAX (Janke-Kunkel) sulphonation flask 1 litre heater 1,5 kW laboratory centrifuges: 4000 rpm thermostated water bath pH meter SMALL glass thermometer rotary vacuum dryer or hot-air dryer Procedures: Into to 1 litre sulphonation flask equipped with to turbostirrer and to heater, 400 mililiter of redistilled H2O to were placed, 15,0 g of 20% Na2CO3 solution to were introduced under stirring. Subsequently, 50 g of oxidised Linters to were added to the white emulsion formed and the contents to were heated up to 95°.C with the stirring intensity set to to maximum. After 10 minutes, 30 g of 30% H2O2 to were added into the flask and the hydrolysis continued for another 10 minutes. The contents to were then cooled down to 60°.C on to water bath and the pH of the system was adjusted to to value of 4. To ice creams some solution (1O g of frosted of in 70 g of redistilled H2O) warmed to 50°.C was added and left to react for another 20 minutes. The flask contents to were then cooled to 30°.C in to water bath and 626 mililiter of synthetic rectified ethanol cone. 98% to were added gradually under intense stirring. The suspension of IMC thus formed was isolated using to laboratory centrifuges. The supernatant liquid was filtered away and the cake was redispersed into 250 mililiter of 50% ethanol. 98% and alllowed stand for 4 hours. It was then centrifuged again, redispersed into 99,9 % isopropanol, and left to stand for to minimum of 10 hours at 20°.C. The gel formed was centrifuged and the product was dried in to rotary vacuum dryer or to hot-air dryer. The product can be used, for instance, for microembolisation, for preparation of haemostatic dusting powders, for manufacture of polymer drugs, and based on cytostatics, or for preparation of spheric particles for macroembolisation. Preparation of Tablets and Pellets from IMC-MDOC Complex magnesium stearate (SIGMA) ascorbic acid (MERCK) α.-tocoferol acetate (Slovakofarma Hlohovec). ethanol synthetic rectified (Chemopetrol Litvinov, to Equipment: tabletting machine (KORSCH EK 0, Berlin) blender (Nautamix 300) counter-flow drier (BINDER) 10 kg of IMC-MDOC complex of composition according to Example 2 to were placed into the blender. 660 g of micronised ascorbic acid, 1660 g of α.-tocoferol acetate emulgated in 2500 mililiter of ethanol and 1000 g of magnesium stearate to were added. The mixture was homogenised for 3 hours and dried in to counter-flow drier at to temperatures of 50°.C until the ethanol was removed. 100 g of the resulting dry powder to were introduced into the tabletting machine. The tabletting force was set at to value of 7 kN. The tablets prepared to were smooth and cohesive and had to weight of 0. Disintegration installments of the tablets in to you go up of it Fl/1 was 17 minutes at 20°.C, and 8 minutes at 37°.C. To patient aged 57, displaying an increased cholesterol content in blood was treated by IMC-MDOC tablets administered orally for 50 days, at to dose of 6 tablets daily. After the treatment both LDL content and total cholesterol content to were significantly reduced. Before Blood analysis treatment after treatment. Example G - Preparation of Granules from MDOC in to Fluid Bed Materials:.m, specific surface area 86 m2/g, COOH group content 22. Set of vibrating screens with mesh size 100, 150, 200, 250, 350, 500.m mixer, bottom agitated, vessel size 1000 mililiter, 8000 rpm, equipped with to nozzle for inlet of the granulation medium counter-flow drier (BINDER) Procedures: 100 g of MDOC to were placed into the mixer, the mixer was closed and the agitation begun. To water mist was gradually injected into the mixer at to installments of 10 g/45 seconds. The granulated formed was transferred to the counter-flow drier and dried at to 45 temperatures of C until the humidity content was reduced to below 6% b/w. The dried granules to were sieve-screened using the set of vibrating screens. The individual fractions to were packaged into glass vials in amounts of 0. The preparation was sterilised by y irradiation with to dose of 25 kGy. The product may be used as to) an embolisation agent, or b) an antilipemicum. Example H - Preparation of Granules from IMC-MDOC Complex Materials: IMC-MDOC complex as prepared in Example 2 Set of vibrating screens with mesh size 100, 150, 200, 250, 350, 500.m mixer, bottom agitated, vessel size 1000 mililiter, 8000 rpm, equipped with to nozzle for inlet of the granulation medium counter-flow drier BINDER. 100 g of MDOC to were placed into the mixer, the mixer was closed and the agitation. Saturated water vapour was gradually injected into the mixer at to installments of 10 g/45 seconds. The granulated formed was transferred to the counter-flow drier and dried at to temperatures of 45°.C until the humidity content was reduced to below 6% b/w. The dried granules to were sieve-screened using the set of vibrating screens. The individual fractions to were packaged into glass vials in amounts of 0. The preparation was sterilised by range irradiation with to dose of 25 kGy. The product may be used as to) an embolisation agent, or b) an antilipemicum. More The invention will be clearly understood from the following Examples thereof given by way of illustration only. The Ethical Committee of the Faculty of Pharmacy, Charles University, approved the protocols of the animal experiments. The protocol of experiments was pursued in accordance with the directive of the Ministry of Education of the Czech Republic (Not mice, generated by gene targeting, have been shown to develop pronounced hypercholesterolemia and atherosclerotic lesions (Reddick ET al., 1994) with certain features resembling those seen in humans (mice Nakashima ET al. on to C57BL/ 6J background (n = 32) weighing 10-15 g to were kindly provided by Prof. Poledne (IKEM, Prague, Czech Republic) and housed in the SEMED, (Prague, Czech Republic). mice to were weaned at 5 weeks of age and randomly subdivided into four groups. The control group of animals (n = 8) was fed with the standards laboratory diet (chow diet) for another 4 weeks after the weaning. In both simvastatin (n = 8) and atorvastatin (n = 8) group, statins to were added to the chow diet at the dosage of 10 mg/kg for day. In MDOC group (n = 8) MDOC was added to the chow diet at the dosage 50 mg/kg for day. Mice All treated were fed with the experimental diet for another 4 weeks after weaning with water to libitum throughout the study. Each mouse, in both statins and MDOC group, lived in to separated cage obtaining 6 g of food (in specially prepared pellets) daily. The food consumption was monitored every day. Not differences in the food consumption were visible, either among animals of one experimental group nor between experimental groups. The dose of simvastatin and atorvastatin used in the present study was based on the doses used in previous studies with hyperlipidemic mice (Laufs ET to. The dose of MDOC was based on the results of to small pilot study. At the end of the treatment period, all animals to were fasted overnight and euthanized. Blood samples to were collected via cardiac puncture at the Time of death. Serum lipoprotein fractions to were prepared using NaCl density gradient ultracentrifugation (Beckman TL 100, High Pole, CA). The lipoprotein fractions to were distinguished in the following density ranges: very low density lipoprotein (VLDL)<.1. Total concentration and lipoprotein fraction concentration of. Sequential tissue sectioning started in the mouse heart until the aortic root containing semilunar valves together with the aorta appeared. From this point on, serial cross- sections (7 Am) to were cut on to cryostat and placed on gelatin-coated slides. Sections to were air-dried and then slides to were fixed for 20 min in acetone at -20, Endogenous peroxidase activity was blocked with 0,3% hydrogen peroxide in phosphate buffered you go up of it (PBS) for 15 min. After blocking of nonspecific binding sites with 10% normal horse serum (Sigma-Aldrich Chemie, Steinheim, Germany) in PBS solution (pH 7,4) for 30 min, slides to were incubated with primary antibodies for 1 h at room temperatures. Antibody reactivity was detected using HRPconjugated biotin- avidin complexes (Vector Laboratories, USA) and developed with substrate diaminobenzidine tetrahydrochloride as. Nonimmune Specificity of the immunostaining was assessed by staining with isotype-matched immunoglobulins. Stereological methods for the estimation of immunohistochemical staining of VCAM-I, ICAM-I, and Von Willebrand factor to were used as previously described (Nachtigal ET to. In brief, the systematic uniform random sampling and the principle of the point-counting method to were used for the estimation (Weibel, 1979). consecutive serial cross-sections to were cut into 7 i'.m thick slices, which gave us 0,350 milimeter lengths of the vessel called the reference volume. To systematic uniform random sampling was used in the reference volume where the parameter: to characterizes the test grid. and P is the number of positive tests points hitting either the atherosclerotic lesion or immunostaining. The area of Von Willebrand factor expression was considered as to total area of intact endothelium. Thus, the area of VCAM-I, and ICAM-I expression indicates the percentage of activated endothelial cells calculated as Where: area (x) is the area of VCAM-I or ICAM-I in the endothelium and area (Von Will) is the area of Von Willebrand factor expression in the endothelium. Ottawa, Canada) and with image analysis software LUCIA version 4,82 (Laboratory Imaging, Prague, Czech Republic). Stereological analysis was performed with to PointGrid module of the ELLIPSE software (ViDiTo, Kosice, Slovakia). All values in the graphs are presented as to meanTSEM of n = 8 animals.05 or less to were considered statistically significant. (g) Atherosclerosis Animals to are to be killed by pentobarbital injection. Thoracic aortas to are rapidly removed, immersion fixed in 10% neutral buffered formalin, and stained with oil red Or (0.) interfaced to to color room (Toshiba 3 CCD) mounted on to dissecting microscope. Tissue cholesterol will be measured enzymatically as described, after extraction with to chloroform/methanol mixture (2:1) according to the method of Folch ET to. The abdominal aortas to are rapidly excised, after injection of sodium pentobarbital, and placed in oxygenated Krebs-bicarbonate buffer. Force changes in response to angiotensin II added to the bath will be recorded on to chart recorder. Total cholesterol, VLDL, LDL, HDL and TAG to were measured. CHOL, HDL-CHOL, TGl and VLDL+LDL) Total serum cholesterol (SER.CHOL) to are to be measured enzymatically using to commercial kit from Wako Fine Chemicals (Richmond, Sigma Chemical Co Total Goes HDL cholesterol (HDL-CHOL) will be assayed using this same kit after precipitation of VLDL and LDL with serum triglycerides (blanked) (TGI) will be assayed enzymatically with Sigma Chemical Co VLDL and LDL (VLDL+LDL) cholesterol concentrations will be calculated as the difference between total and HDL cholesterol. Biochemical analysis showed that statins treatment did not decrease levels of total cholesterol and VLDL (Fig. By contrast, atorvastatin treatment increased levels of the total serum cholesterol in comparison to the control group (23, However, MDOC treatment decreased total serum cholesterol in comparison to the control group (17, Example 2 - Endothelial expression of VCAM-I in apoE. Members of the immunoglobulin superfamily of endothelial adhesion molecules, vascular cell adhesion molecule (VCAM-I) and intercellular cell adhesion molecule (ICAM-I) strongly participate in leukocyte adhesion to the endothelium and play an important role in all stages of atherogenesis. Immunohistochemical staining of VCAM-I and ICAM-I. Not atherosclerotic lesion or other morphological abnormalities in the aortic arch were visible in any mice in the experiment. The expression of VCAM-I and ICAM-I was observed in vessel endothelium in all groups of animals (Fig. Furthermore, ICAM-I expression was stronger then VCAM-I in each experimental group. Moreover, ICAM-I expression decreased in both statins (Fig. 2d) treated mice compared to the control group (Fig. The same results to were observed even for VCAM-I staining (Fig. However, the strongest diminution of mice ICAM-I and VCAM-I expression was visible in the atorvastatin treated (Fig 2c, 3c). Mice Results of the stereological analysis confirmed that ICAM-I staining was much stronger in all compared to the VCAM-I staining (Fig. percentage of activated endothelial cells ICAM-I /von Willebrand slightly decreased in simvastatin (22,12 %) treated animals in comparison to the control mice. However, significant diminution of both ICAM-1/von Willebrand (2,001) staining was observed in atorvastatin treated animals in comparison to the control group (Fig. In addition, VCAM- 1/von Willebrand staining significantly decreased even in MDOC treated animals (3, Example 3 —. Mice VCAM expression in activated endothelial cells on to C57BL/6J background (n=24) were weaned at 5 weeks of age and randomly divided into 3 groups. Control group (n=8) - mice consumed to standard diet for 4 weeks (6 g of diet for day). MDOC group (n=8) - mice consumed to standard diet supplemented with MDOC (50 mg/kg for day) for 4 weeks (6 g of diet for day). Atorvastatin group (n-8) - mice consumed to standard diet supplemented with atorvastatin (10 mg/kg for day) for 4 weeks (6 g of diet for day). Not differences in the average weekly food consumption and body weight were detected during the study. At the end of the treatment all animals to were fasted overnight, and euthanized. Blood samples to were collected at the Time of death via cardiac puncture. Sequential 20 μ.m sections of the aortic lumen to were cut, dried and fixed. Estimation of immunohistochemical staining of VCAM-I and ICAM-I was carried out. systematic uniform random sampling and the principle of point cutting to were used for this determination. Fifty consecutive serial cross sections to were cut in to 7 μ.m thick slices. Each tenth section was used, thus five sections for each staining to were used for the stereological estimation. The area of von Willebrand factor expression was considered as to total area as the total area of intact endothelium. Thus, the area of VCAM and ICAM expression is defined as the percentage of the von Willebrand factor expression (the This method is described in more detail in Nachtigal ET to (2004). The percentage of VCAM expressing activated endothelial cells was calculated as described in the study design section. The results for the control, atorvastatin and MDOC groups to were compared and the means to were plotted in Figures 5. Table 2 —. Statistical results for VCAM expression in the control, atorvastatin and MDOC groups. The results presented in Figures 5 demonstrate that atorvastatin treatment greatly reduced the expression of VCAM (pO. The MDOC group also had to significantly reduced VCAM expression (pO. These pre-clinical studies have demonstrated that MDOC is able to significantly decrease (77%) the expression of VCAM-I in the aorta. Therefore VCAM is intimately linked to the development of atherosclerotic plaques and its reduction by MDOC may decrease the chance of atherosclerosis. This conclusion adds further valuable evidence for to significant role in cardiovascular disease reduction by MDOC. The mechanism by which this effect occurs is most likely two to the dietary reduction of LDL by MDOC. Atherosclerotic arteries produces excess reactive oxygen species such as super oxide anion Or Oxidised LDL (oxLDL) accumulates in the atheroma and promotes macrophage survival and growth and monocyte proliferation and hence foam cell development. The lowering of LDL by MDOC may therefore veteran the amount of oxLDL produced. Hence, the reduced accumulation of oxLDL might contribute to decreased numbers of macrophages in atheroma during lipid lowering and hence the atherosclerotic risk. This shows the potential of the hypolipidemic substance MDOC to decrease endothelial expression of VCAM-I in very early stages of atherogenesis. This potential anti inflammatory effect may be related to the mild hypolipidemic effect of MDOC. Rats with to body weight of approximately 175g were obtained from Charles River Laboratories, Ballina, Ireland. After 1 wk of acclimation, 80 rats to were allocated to 4 similar groups (n = 20 for group) on the basis of their body weight. The rats to were housed in groups of two and three in dust-free standards cages with autoclaved processed sawdust as bedding material. The rats to were housed in an environmentally controlled room (temperatures 22 ±. 3°.C) with to 12-h lightrdark cycle. Throughout the study, the rats had free access to food and drinking water. Clinical observation and body weight measurement to were conducted weekly. -- During the adaptation period, rats to were fed the AIN-93 synthetic diet for one week. Subsequently, all rats to were fed the AIN-93 diet supplemented with 3% cholesterol for another week (High cholesterol diet. HCD). During the experimental period the rats to were divided into 4 groups and to were fed different diets for 4 weeks according to Table 3. The diets to were prepared in pellet form by Special Diet Services, Essex, England.The High Cholesterol Diet (HCD) fed to the rats was supplemented for each group as described below. Oxidised celluloses (OC) MDOC was prepared as described above. Generic sterols (Gen) to were purchased from commercially available products. One-way ANOVA to are used to determine treatment differences (SigmaStat version 1. Differences among means will be inspected using appropriated multiple comparisons test and to were considered significant at P<.0. Not difference across treatments in final body weights was observed (p >. 0. Weight gain during the course of the study for the control group and for the three treatment groups. Example 5 - combination therapy changes in LDL cholesterol. Blood was allowed to clot and then transferred to to refrigerated 10 centrifuges and centrifuged at 2,500 rpm for minutes at 2-8°.C. The collected serum was frozen at —.20. Serum LDL and HDL-cholesterol to were measured enzymatically by using commercial available kits (EZ LDL™., EZ HDL™.: Cholesterol kits, Trinity Biotech). Total cholesterol was measured using the commercially available kits from Human, Germany. Serum glucoses was determined by colorimetric glucoses oxidase assay (Sigma-Aldrich). Triglycerides to were measured with to commercially available kit from Sigma-Aldrich. -- One-way ANOVA to are used to determine treatment differences (SigmaStat version 1. Differences among means will be inspected using appropriated multiple comparisons test and to were considered significant at P<.0. Table 5 The effect of the dietary supplementation of to High Cholesterol Diet (HCD) with 1% oxidized celluloses (OC) MDOC and 0,5% sterol (w/w) on the serum LDL cholesterol concentrations in rats (n-20/gp) fed these diets. The differences in the mean values among the treatment groups are greater than would be expected by chance. to there is to statistically significant difference (p<.0. All Pairwise Multiple Comparison Procedures (Student-Newman-Keuls Method):. Table 5 illustrates an example of to combination therapy of the present invention. The example comprises four groups of subjects and the effectes on LAL (bad) cholesterol reduction. The four groups to are: to control group that received not agent. to group that receive 1% (w/w) oxidised celluloses (OC) MDOC. to group that received 0,5% (w/w) sterol. and to final group that received both the 1% (w/w) OC MDOC and the 0. As can be seen from Figures 7, the combination of 0,5% sterol (w/w) caused to greater decrease in the level of LDL (bad) cholesterol than either 0. Therefore the combination of OC (MDOC) and sterol is more effective as an anti-atherosclerosis or an anti-hyperlipidemic. Example 6 - combination therapy, changes in total cholesterol. Blood was allowed to clot and then transferred to to refrigerated 10 centrifuges and centrifuged at 2,500 rpm for minutes at 2-8°.C. The collected serum was frozen at —.20. Serum LDL and HDL-cholesterol to were measured enzymatically by using commercial available kits (EZ LDL™., EZ HDL™.: Cholesterol kits, Trinity Biotech). Total cholesterol was measured using the commercially available kits from Human, Germany. Serum glucoses will be determined by colorimetric glucoses oxidase assay (Sigma -. Triglycerides to were measured with to commercially available kit from Sigma -. One-way ANOVA to are used to determine treatment differences (SigmaStat version 1. Differences among means will be inspected using appropriated multiple comparisons test and to were considered significant at P<.0. Table 6 The effect of the dietary supplementation of to High Cholesterol Diet (HCD) with 1% oxidized celluloses (OC) MDOC and 0,5% sterol (w/w) on the serum Total cholesterol concentrations in rats (n=20/gp) fed these diets. The differences in the mean values among the treatment groups are greater than would be expected by chance. to there is to statistically significant difference (p=0. All Pairwise Multiple Comparison Procedures (Student-Newman-Keuls Method):. All other comparisons to are not significant. Table 6 illustrates an example of to combination therapy of the present invention. The example comprises four groups of subjects and the effectes on LAL (bad) cholesterol reduction. The four groups to are: to control group that received not agent. to group that receive 1% (w/w) oxidised celluloses (OC) MDOC. to group that received 0,5% (w/w) sterol. and to final group that received both the 1% (w/w) OC (MDOC) and the 0. As can be seen from Figures 8, the combination of 0,5% sterol (w/w) caused to greater decrease in the level of total cholesterol than either 0. (MDOC) and sterol is more effective as an anti-atherosclerosis or an anti-hyperlipidemic. Rats with to body weight of approximately 175g were obtained from Charles River Laboratories, Ballina, Ireland. After 1 wk of acclimation, 30 rats to were allocated to 3 similar groups (n = 10 for group) on the basis of their body weight. The rats to were housed in groups of two and three in dust-free standards cages with autoclaved processed sawdust as bedding material. The rats to were housed in an environmentally controlled room. Throughout the study, the rats had free access to food and drinking water. Clinical observation and body weight measurement to were conducted ounces to week. During the adaptation period, rats to were fed the AIN-93 synthetic diet for one week. Subsequently, all rats to were fed the AIN-93 diet supplemented with 1% cholesterol for another week (High cholesterol diet. HCD). During the experimental period the rats to were divided into three groups and to were fed different diets for 25 days. The first group was fed the AIN-93 diet supplemented with 1% cholesterol. The second and third groups. to were also fed the AIN-93 diet supplemented with 1% cholesterol and 1% or 5% oxidized celluloses respectively. The diets to were prepared in pellet form by Special Diet Services, Essex, England. OC (MDOC) was prepared as described above. One-way ANOVA was used to determine treatment differences (SigmaStat version 1. Differences among means to were inspected using Tukey multiple comparisons test and to were considered significant at P<.0. If normality test failed non-parametric tests to were used. The Kruskal-Wallis non-parametric ANOVA test was performed with multiple Dunn'.s post ANOVA comparisons test. The three treatment groups started with similar mean body weights that to were not statistically different from each other. These mean body weights ranged from 256. To summary of the body weights is provided in Figures 9 and the weight gain over the course of the study is also presented. Table 7 Weight gain during the course of the study for the control group and for the two treatment groups. All rats gained weight during the study period with not differences across treatments in final body weights (p >. 0. Blood was allowed to clot and was then transferred to to refrigerated 10 centrifuges and centrifuged at 2,500 rpm for minutes at 2-8°.C. The collected serum was then frozen at —.20. One-way ANOVA was used to determine treatment differences (SigmaStat version 1. Differences among means to were inspected using Tukey multiple comparisons test and to were considered significant at P<.0. If normality test failed non-parametric tests to were used. The Kruskal—. Wallis non-parametric ANOVA test was performed with multiple Dunn'.s post ANOVA comparisons test. The results of the fasting serum glucoses levels to are presented in Figures 10. These results indicated to reduction in the serum glucoses in the rats fed to HCD supplemented with MDOC. The group of rats fed the HCD supplemented with 5% MDOC (w/w) significantly reduced the glucoses concentration in the serum to 90. Fasting blood glucoses concentrations in the rats fed the HCD supplemented with 5% MDOC was significantly decreased (~9%) compared to the control group. This result may have very interesting possibilities for management of diabetes mellitus. CHD is to long-term complication of diabetes mellitus. The American Diabetes Association recognized the relationship of diabetes and CHD. It has documented goals of which optimal serum lipid levels, as well as maintenance of near-normal blood glucoses levels to are of primary importance (ADA, 2000). The potential of MDOC to manage both the glucoses and serum lipid levels may be of great significance to diabetes mellitus sufferers. The examples herein can be performed by substituting the generically or specifically described therapeutic compounds or inert ingredients for those used in the preceding examples. Hereinbefore The invention is not limited to the embodiments described which may be varied in detail. Morphology of the endothelium over atherosclerotic plaques in human coronary arteries. Expression of inflammatory mediators and adhesion molecules in human atherosclerotic plaque. The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation. Pleiotropic effects of statins and their clinical significance. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. The application of stereological methods for the quantitative analysis of the atherosclerotic lesions in rabbits. Application of stereological methods for the quantification of VCAM-I and ICAM-I expression in early stages of rabbit atherogenesis. Mice ApoE-deficient develop lesions of all phases of atherosclerosis throughout the arterial tree. Upregulation of VCAM-I and ICAM-I at atherosclerosis-prone sites on the endothelium in the ApoEdeficient mouse. Arteriosclerosis Thrombosis and Vascular Biology 18, 842 —. 851. Evaluation of lesional development and progression. Simvastatin has anti-inflammatory and antiatherosclerotic activities independent of plasma cholesterol lowering. Arteriosclerosis Thrombosis and Vascular Biology 21, 115 - 121.Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Statins I give more than just lower cholesterol. Practical Methods for Biology Morphometry, vol. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein And Recevoir DES mises à. jour par courrier é.lectronique concernant les activité.s de OMPI sur les brevets ET the PCT